For dogs, 10-20 Kg ( 22-44 lbs) Frontline Combo Medium Dog contains fipronil 134 mg, (S)-methoprene 120.60 mg, butylhydroxyanisole (E320) and butylhydroxytoluene (E321) in a pipette of 1.34ml solution. Indicated to be used bi-monthly against infestations with fleas, and for the treatment of ticks and/or biting lice. Prevention of the multiplication of fleas by inhibiting the development of eggs, larvae and pupae originating from eggs laid by adult fleas for 6 weeks after application.