Preclinical and human experiences Amino acids and their role in the process of metabolism Amino acids play a central role both as building blocks of proteins and as intermediates in metabolism. From the 20 standard proteinogenic amino acids, 8 are called essential amino acids, because the human body cannot synthesize them from other compounds, so they must be obtained from food. However, the situation is a little more complicated: the cysteine, tyrosine, histidine and arginine are semiessential amino acids in childhood, because the metabolic pathways that synthesize these amino acids are not fully developed in a childís body. Our organism reuses 75% from the produced amino acids for the production of own proteins, and 25% as power source. While reserve does not originate from the produced amino acids (for example: fatty acids, glucose), the own histic proteins are demolished in case of need, mainly from the muscular tissue. ? Our liver plays the main role in the synthesis of the proteins, furthermore in its metabolism and in the enzymatic processes. If our liver is damaged (viral infectious hepatitis, side effects of medicaments and chemotherapeutic methods, alcohol etc.), it is not able to play its important part in metabolism. So it is obviously very important to protect the liver. In case of a liver damage, the medicinal therapy and a change of lifestyle are also crucial. Most of the final products of the detoxifying processes get back into the circulation and defecate with the urine. Part of them get into the gall bladder, then into the duodenum. These facts are important in order to understand the diseases of the liver and their symptoms. The amino acids - which contain Sulphur - contribute to the glutation synthesis, increasing its level hereby. The glutation is the main detoxifying substance of the liver since it plays a role in binding a lot of toxins. The antioxidants defend the membrane of the liver cells against the damaging effects of the toxins. Not only the traditionel antioxidants are important (vitamin C, vitamin E, fatty acids etc.), but the enzymes which eliminate the free radicals (SOD, glutation peroxidase) are also crucial. In the past 8-10 years, we have been working on the development of a product that supports the functions of the liver. Primarily, we were looking for combinations of amino acids, which donít have any reference in the medicinal literature as yet as regenerating and repairing agents. We found a molecule that fitted very well into our research aims. This agent is called vitamin U, in chemistry known as S-metil-metionin. The appropriation of this agent as food supplement has been protected with an international patent. The definitive combination of the product has been tested in preclinical experiments, primarily in the examination of anti-cancer agents side effects. Specialists examinated test persons who were applied Ergeron according to the daily assessed dose in different liver-toxicosis. The most visible improvement of the blood tests was achieved in patients suffering from hepatitis C. The earlier positive test had turned negative in two incidents! ?We are planning additional examinations now that we are in the possession of these experiences, primarily in order to observe the biochemical changes. The metabolism of the amino acids and ammonia The majority of the amino acids is decaying to urea in the liver, just a few of them get into the circulation as free amino acid. The function of the amino acids is hampered in serious liver insufficiency, accordingly the quantity of free amino acids in the circulation grows. That causes aminoacidurie, which means an increased amino acid excretion with the urine. The toxic product of the nitrogen metabolism, the ammonia (NH3), is nearly completely transformed in the liver into non-toxic metabol (carbamid) in the urea-cycle. The urea synthesis decreases in advanced liver diseases, and the ammonia-level increases in the blood. This rising may damage the cerebral functions. Therapeutic methods which increase the serum ammonia level can have a progressive effect. Vitamin U For the time being, there is no other multi-vitamin or food-supplement material that contains Vitamin-U. Vitamin-U, the S-methyl-methionine, is an excellent antioxidant. This component affects all the parts of the organism, but most of all the cell membranes. On the cell membranes, Vitamin-U transforms the hard-to-eliminate molecules, or molecules that never leave the organism, and gets rid of them by way of metabolism. By doing so, it supports molecules needed to build Ągood cellsĒ. These so-called Ąclean moleculesĒ, like amino acids, play an important role in the DNA synthesis. The aim of our research was to maintain the lowest chance for íbroken moleculesí to participate in DNA synthesis, since these molecules change the chain-molecule sequence that may result from false cells during cell division. If such a false cell divides once again, it generates cancer cells. Vitamin-U plays the role of the ícell membrane cleanerí, thus preventing metastases in cancer patientsí bodies. Vitamin-U also acts as carrier for fat-soluble vitamins, selenium and beta carotene. That is to say, it helps the assimilation of these vitamins and leads them to the place of utilization in the body. The Vitamin-U strengthens the immune system by cleaning the way for building the albumins needed for the immune system. L-cystein † The SH group of L-cystein is capable of rebuilding the cell membrane. In case of hypoxia and oedema (mainly in the brain), cell membranes are broken, which results in cell plasm leaking out of the cells, further deteriorating the state of hypoxia and oedema. L-cystein repairs the cell membranes, restores permeability conditions, therefore hypoxia and oedema loose intensity. It is an excellent antioxidant. When cells are affected by cancer, they suffer from hypoxia. Itís important to mention glutation. This molecule is built from three amino acids (a cysteine, glutamine and glycin). The cysteine can limit the glutation synthesis. The level of the cysteine determines how much glutation is produced. So it is most important to take cysteine from the outside; this contributes to the glutation synthesis and to the increase of the glutation level. The glutation conjugation is the process in which 60% of the toxic substances are binded in the liver (in the second phase of the detoxifying process). The efficiency of this contributes to the fact that the toxins do not accumulate in the liver. Nevertheless, the cysteine is an efficient antioxidant and an additional protection for the liver cells. It helps to stabilize the cell membranes and neutralize the toxic metabolits which synthezise while digesting fats and alcohol. It protects our body from tobacco smoke, heavy metals and a lot of deleterious effects of other substances. L-glutamic acid The L-glutamic acid is capable of blocking the unnecessary nitrogene in the brainís circulatory system, and as a consequence causes a better brain function. Its efficacy depends on the glucose level. L-glutamic acid reduces the sugar hunger. It helps to remove the ammonia from our body and increases the level of some strong antioxidants. So it plays a role in the detoxifying process of the body (alcohol detoxication). Comment: It is recommended to take it combined with B-complex and vitamin C. L-aspartic acid The L-aspartic acid supports an optimal function of the cells. It declines quickly by patients suffering from cancer, then it is necessary to recover it. ?By using it combined with L-glutamic acid it decreases the demolition of the own proteins and hereby accelerates the intellectual and physical regeneration of the human organism. † Ornitine Supports the immune system Eliminates the ammonia from the body and thus assists regeneration Plays a role in regeneration of the liver, too, because it discharges the toxic agents and increases the proof against the toxines Helps recovery from wounds The level of the ornitine decreases after a trauma or injuries It helps when we adapt to the stress. Methionin Methionin is an essential amino acid, it is a component of proteins. It is a strong antioxidant, protecting from free radicals and helping to build muscles. It plays an important role in RNA and DNA synthesis. It prevents demolition of muscles and helps to conservate the elasticity of the skin and its health. Methionin strengthens fingernails and hair. Symptoms of the deficiency: Decreased ability to urinate Oedemas Decreased resistance against infections Damaged protein synthesis Cataract Research shows that metionin can be useful in treatment of and regeneration from alcoholism. Metionin helps to demolish fats and repairs the lecithin-producing ability of the liver. Since it can turn into a cysteine, the metionin plays a role in neutralizing toxins.

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