The Sign of Four is a mystery novel by Sir Arthur Conan Doyle featuring the fictional character Sherlock Holmes. The story was first published in serial form in Lippincott's Monthly Magazine in 1890.
At the outset of the novel Doctor Watson states that he has been watching Holmes takes cocaine three times a day for many months. Watson's reluctance to oppose Holmes is finally overcome and he confronts his friend about the potential ill effects of this prolonged usage.
Holmes explains that he finds the drug stimulates and clarifies his mind and that without work to challenge his mental faculties he becomes bored with day to day life.
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